Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma.

International audienceABSTRACT: BACKGROUND: The purpose of the present study was to compare side-by-side the therapeutic efficacy of a 6-day infusion of carboplatin, followed by X-irradiation with either 6 MV photons or synchrotron X-rays, tuned above the K-edge of Pt, for treatment of F98 glioma bearing rats. METHODS: Carboplatin was administered intracerebrally (i.c.) to F98 glioma bearing rats over 6 days using AlzetTM osmotic pumps starting 7 days after tumor implantation. Radiotherapy was delivered in a single 15 Gy fraction on day 14 using a conventional 6 MV linear accelerator (LINAC) or 78.8 keV synchrotron X-rays. RESULTS: Untreated control animals had a median survival time (MeST) of 33 days. Animals that received either carboplatin alone or irradiation alone with either 78.8 keV or 6 MV had a MeSTs 38 and 33 days, respectively. Animals that received carboplatin in combination with X-irradiation had a MeST of > 180 days with a 55% cure rate, irrespective of whether they were irradiated with either 78.8 KeV synchrotron X-rays or 6MV photons. CONCLUSIONS: These studies have conclusively demonstrated the equivalency of i.c. delivery of carboplatin in combination with X-irradiation with either 6 MV photons or synchrotron X-rays

Linking people, places and products. A guide for promoting quality linked to geographical origin and sustainable geographical indications

The designations employed and the presentation of material in this information product do not imply the expression of any opinion whatsoever on the part of the Food and Agriculture Organization of the United Nations (FAO) concerning the legal or development status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or products of manufacturers, whether or not these have been patented, does not imply that these have been endorsed or recommended by FAO in preference to others of a similar nature that are not mentioned. The views expressed in this information product are those of the author(s) and do not necessarily reflect the views of FAO. The views expressed in the contribution by SINER-GI members are the sole responsibility of the authors and do not necessarily reflect the views of the European Commission. Neither the European Commission nor any person acting on behalf of the Commission is responsible for the potential use of the information contained herein

Wege in die Ernährungszukunft der Schweiz - Leitfaden zu den grössten Hebeln und politischen Pfaden für ein nachhaltiges Ernährungssystem

Aus wissenschaftlicher Sicht ist klar: Unser Ernährungssystem ist nicht nachhaltig. Um unsere Lebens- und Wirtschaftsgrundlagen zu erhalten, braucht es eine Neuausrichtung über die gesamte Wertschöpfungskette. Diese ist gleichzeitig ein Schlüssel zur Erreichung der Agenda 2030 für nachhaltige Entwicklung. SDSN Schweiz hat das wissenschaftliche Gremium Ernährungszukunft Schweiz initiiert, um einen Wegweiser zu entwickeln. Er soll es der Schweiz erlauben, Chancen rechtzeitig anzupacken und unkontrollierbare Kostenfolgen zu vermeiden. Das wissenschaftliche Gremium hat international wegweisende Pionierarbeit geleistet. In einem interdisziplinären wissenschaftlichen Prozess wurde zum ersten Mal für ein Land ein umfassender Handlungspfad zur Neuausrichtung des Ernährungssystems im Einklang mit den Zielen für nachhaltige Entwicklung ausgearbeitet. Die beteiligten Forschenden schaffen damit eine wichtige Grundlage für die weitere politische Diskussion in der Schweiz und international

Overview of consumer research in Western Balkan countries

A set of 205 publications from Western Balkan countries was gathered and systematically ordered as an action of the EU project ‘Focus Balkans – Food Consumer Sciences in the Balkans’. Six country reports provided the base data. Methodologically, publications were split up by the use of primary or secondary data or both, as well as being a qualitative or quantitative study. Qua research concept focus on the individual (human being), on the environment or on the product itself was analysed. As research tools interviews, focus groups and experiments as well as surveys, questionnaires and on-line panel data were considered. There is in general a lack of primary data, and a disproportion between qualitative and quantitative studies in favour of quantitative in the WBC. The majority of publications gathered were ‘environment’ oriented. There is somewhat less focus on fruit than on other product groups, being organic, traditional and health claimed. Use of interviews and written questionnaires is by far the most popular. On-line panels are not yet utilized. A study of keywords listed gave quite a useful and objective impression concerning the emphasis on different topics in the various WBC publications under consideration. The keywords indicate a focus on ‘market’ and ‘marketing’ research in most countries. Consumer ‘behaviour’ and ‘attitude’ are less listed as a main keyword, while, remarkably, ‘obesity’ as concept is hardly mentioned. It was noted that the ‘house’ of scientific expertise in this field has, perhaps, a poor foundation, while ‘the pillars behind consumer science’ are not interrelated and fastened together. Indeed, a multidisciplinary approach is rare. There is also a lack of interaction with the international community. By far the most publications are published in the local languages and nearly all are written by local authors. Some of the countries conclude that there is a huge knowledge gap on food consumers’ science and that should be used as a stimulus for developing further research and knowledge transfer in this field

Radiation Therapy Using Synchrotron Radiation: Preclinical Studies Toward Clinical Trials

International audienceAfter decades of intensive research, high-grade gliomas are still resistant to therapies, including surgery, chemotherapy, and radiotherapy or a combination thereof. The most important advance in the treatment of these tumors has been the introduction of a new chemotherapy drug called temozolomide, in combination with external beam photon irradiation [1]. One of the goals of the association of the CHU/UJF/ INSERM and ESRF teams has been to develop research on synchrotron radiotherapy up to clinics